During Isaac Challenge Sunday, I took on a challenge that restricted me from picking up any items that changed Isaac's physical appearance. Dr. Fetus changes Isaac's physical appearance. Witness my reaction.
There were no expectations of success during this run, especially after grabbing the Dead Cat and turning Samson into Guppy. But that, along with the Nail + Nun's Habit combo (and a healthy dose of lag) allowed me to complete a Chest run as Samson.